Affiliation:
1. Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States
Abstract
Epidemiological data demonstrate greater cardiovascular risk in patients with previous heat stroke exposure. Using a preclinical mouse model of exertional heat stroke, male mice were exposed to one of three environmental temperatures (Te) during exercise. Paradoxically, after 2 wk, the mice in the lowest Te, exhibiting the largest exercise response and lowest heat load, had the greatest ventricular metabolic disturbances. Metabolic outcomes resemble developing left ventricular hypertrophy or stress-induced heart disease.
Funder
University of Florida Foundation
DOD | United States Army | MEDCOM | U.S. Army Medical Research and Development Command
HHS | NIH | NHLBI | NHLBI Division of Intramural Research
KSU | College of Medicine, King Saud University
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology