Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice

Author:

Ohira Takashi12,Ino Yoko2,Kawao Naoyuki1,Mizukami Yuya1,Okada Kiyotaka1,Matsuo Osamu1,Hirano Hisashi2,Kimura Yayoi2,Kaji Hiroshi1ORCID

Affiliation:

1. Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine, Osaka, Japan

2. Advanced Medical Research Center, Yokohama City University, Kanagawa, Japan

Abstract

The expression levels of fibrinolysis-related proteins, including plasminogen, were significantly elevated in the gastrocnemius (Gast) and soleus muscles of mice following 30-day microgravity exposure. Plasminogen deficiency exacerbated atrophy of the Gast, but not the soleus, muscles in mice following 21-day hindlimb suspension. It was also suggested that protein breakdown via the autophagy-lysosome system was accelerated in the Gast muscles. Plasminogen might play some protective roles against muscle atrophy induced by mechanical unloading in developing mice.

Funder

The Japan Aerospace Exploration Agency

Japan Society for the Promotion of Science

Publisher

American Physiological Society

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