Physiological determinants of decreased peak leg oxygen uptake in chronic disease: a systematic review and meta-analysis-Reference-Cited by-同舟云学术

Physiological determinants of decreased peak leg oxygen uptake in chronic disease: a systematic review and meta-analysis

Published:2024-06-01 Issue:6 Volume:136 Page:1293-1302
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Foulkes Stephen J.¹²³^ORCID,Wagner Peter D.⁴^ORCID,Wang Jing⁵,La Gerche Andre³^ORCID,Haykowsky Mark J.¹^ORCID

Affiliation:

1. Integrated Cardiovascular and Exercise Physiology and Rehabilitation (iCARE) Laboratory, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

2. Cardiometabolic Health and Exercise Physiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

3. Heart, Exercise and Research Trials Lab, St Vincent’s Institute of Medical Research, Melbourne, Victoria, Australia

4. Department of Medicine, University of California, San Diego, California, United States

5. Division of Public Health, School of Medicine, University of Utah, Salt Lake City, Utah, United States

Abstract

Peripheral (skeletal muscle and vasculature) factors contribute significantly to reduced exercise capacity during both large and small muscle mass exercise in chronic diseases such as COPD, HFrEF, or RF and should be important targets of therapy in addition to the primary organs (lungs, heart, and kidneys) affected by disease.

Funder

University of Alberta

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00918.2023

Reference45 articles.

1. Determinants of the diminished exercise capacity in patients with chronic obstructive pulmonary disease: looking beyond the lungs

2. Limited Maximal Exercise Capacity in Patients With Chronic Heart Failure

3. Impaired muscle oxygen transfer in patients with chronic renal failure

4. Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure.

5. Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD

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