Changes in ventricular twist and untwisting with orthostatic stress: endurance athletes versus normally active individuals

Abstract

Endurance-trained individuals exhibit larger reductions in left ventricular (LV) end-diastolic volume in response to lower body negative pressure (LBNP) compared with normally active individuals. However, the relationship between LV torsion and untwisting and the LV volume response to LBNP in endurance athletes is unknown. Eight endurance-trained athletes [maximal oxygen consumption (V̇o2max): 66.4 ± 7.2 ml·kg−1·min−1] and eight normally active individuals (V̇o2max: 41.9 ± 9.0 ml·kg−1·min−1) (all men) underwent two cardiac magnetic resonance imaging (MRI) assessments, the first during supine rest and the second during −30 mmHg LBNP. Right ventricular (RV) and LV volumes were assessed, myocardial tagging was applied in order to quantify LV peak torsion and peak untwisting rate, and filling rates were measured with phase-contrast MRI. In response to LBNP, endurance-trained individuals had greater reductions in RV and LV end-diastolic volume and stroke volume ( P < 0.05). Endurance athletes had reduced untwisting rates (20.3 ± 8.7°/s), while normally active individuals had increased untwisting rates (−16.2 ± 32.1°/s) in response to LBNP ( P < 0.05). Changes in peak untwisting rate were significantly correlated with change in peak torsion ( R = −0.87, P < 0.05), with the change in early filling rate and V̇o2max, but not with changes in end-diastolic or end-systolic volume ( P > 0.05). We conclude that increased untwisting rates in normally active subjects may mitigate the drop in early filling rate with LBNP and thus may be a compensatory mechanism for the reduction in stroke volume with volume unloading. The opposite response in athletes, who showed a decreased untwisting rate, may contribute to their larger reductions in LV end-diastolic and stroke volumes with volume unloading and their orthostatic intolerance.