Negligible influence of moderate to severe hyperthermia on blood-brain barrier permeability and neuronal parenchymal integrity in healthy men

Author:

Shepley Brooke R.1,Ainslie Philip N.2,Hoiland Ryan L.23ORCID,Donnelly Joseph4,Sekhon Mypinder S.25,Zetterberg Henrik6789,Blennow Kaj67,Bain Anthony R.1

Affiliation:

1. Faculty of Human Kinetics, Department of Kinesiology, University of Windsor, Windsor, ON, Canada

2. Centre for Heart Lung and Vascular Health, University of British Columbia, Kelowna, Vancouver, BC, Canada

3. Department of Anesthesiology, Pharmacology, and Therapeutics, Vancouver General Hospital, Vancouver, BC, Canada

4. Brain Physics Laboratory, Division of Academic Neurosurgery, Department of Clinical Neurosciences, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom

5. Division of Critical Care Medicine and Department of Medicine, University of British Columbia, Vancouver, BC, Canada

6. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

7. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

8. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom

9. UK Dementia Research Institute at UCL, London, United Kingdom

Abstract

The acute effects of passive whole-body hyperthermia on the integrity of the neurovascular unit (NVU) in humans have remained unclear. We demonstrate that passive heating for ∼1 h until an increase of +2°C esophageal temperature in healthy men does not increase the cerebral release of neuronal parenchymal stress biomarkers, suggesting the NVU integrity is maintained. This preliminary study indicates passive heating is safe for the brain, at least in young healthy men.

Funder

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada

Vetenskapsrådet

Alzheimer's Drug Discovery Foundation

European Research Council

Swedish State Support for Clinical Research

UK Dementia Research Institute

Alzheimerfonden

Hjärnfonden

EU Joint Programme - Neurodegenerative Disease Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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