Physiologically variable ventilation prevents lung function deterioration in a model of pulmonary fibrosis-Reference-Cited by-同舟云学术

Physiologically variable ventilation prevents lung function deterioration in a model of pulmonary fibrosis

Published:2022-04-01 Issue:4 Volume:132 Page:915-924
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Dos Santos Rocha André¹^ORCID,Peták Ferenc²^ORCID,Carvalho Tânia³,Habre Walid¹⁴,Balogh Adam L.¹

Affiliation:

1. Unit for Anaesthesiological Investigations, Department of Acute Medicine, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland

2. Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary

3. Histology and Comparative Pathology Laboratory, Instituto de Medicina Molecular, Lisbon, Portugal

4. Pediatric Anesthesia Unit, Geneva Children’s Hospital, Geneva, Switzerland

Abstract

The superposition of physiological breathing variability onto a conventional pressure signal during prolonged mechanical ventilation prevents atelectasis development in bleomycin-induced lung fibrosis. This advantage is evidenced by reduced deterioration in tissue mechanics, end-expiratory lung volume, ventilation homogeneity, and gas exchange.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00670.2021

Reference51 articles.

1. Biologically variable ventilation prevents deterioration of gas exchange during prolonged anaesthesia

2. Biologically Variable or Naturally Noisy Mechanical Ventilation Recruits Atelectatic Lung

3. Improved Arterial Oxygenation with Biologically Variable or Fractal Ventilation Using Low Tidal Volumes in a Porcine Model of Acute Respiratory Distress Syndrome

4. Variable Tidal Volume Ventilation Improves Lung Mechanics and Gas Exchange in a Rodent Model of Acute Lung Injury

5. Combined Effects of Ventilation Mode and Positive End-Expiratory Pressure on Mechanics, Gas Exchange and the Epithelium in Mice with Acute Lung Injury

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