A simulation of skin mitochondrial P<scp>o</scp><sub>2</sub> in circulatory shock-Reference-Cited by-同舟云学术

A simulation of skin mitochondrial Po₂ in circulatory shock

Published:2023-05-01 Issue:5 Volume:134 Page:1165-1176
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Hilderink Bashar N.¹^ORCID,Crane Reinier F.¹,Baysan Meryem²,Arbous Sesmu M.²,van den Bogaard Bas¹,Mik Egbert G.³,Ince Can⁴,Pillay Janesh⁵,Juffermans Nicole P.¹⁴

Affiliation:

1. Department of Intensive Care, OLVG Hospital, Amsterdam, The Netherlands

2. Department of Intensive Care, Leiden University Medical Center, Leiden, The Netherlands

3. Laboratory of Experimental Anesthesiology, Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands

4. Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

5. Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Abstract

This is the first paper to simulate mitochondrial oxygen tension in skin in circulatory shock. The relationships of mitoPo2 with parameters of (microcirculatory) oxygen delivery aid in the understanding of noninvasive bedside measurement of mitoPo2 values and show that mitochondrial oxygen tension is two orders of magnitude higher than classically assumed. The model can be used to enhance clinical trial design investigating mitoPo2 as a resuscitation target in circulatory shock.

Funder

European Society of Intensive Care Medicine

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00621.2022

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