CORP: Sources and degrees of variability in whole animal intermittent hypoxia experiments

Author:

Zhang Zishan12,Kalra Hardik3,Delzell Matthew C.34,Jedlicka Charles R.3,Vasilyev Mikhail2,Vasileva Anastasiia3ORCID,Tomasson Michael H.123,Bates Melissa L.1235ORCID

Affiliation:

1. Interdisciplinary Graduate Program in Molecular Medicine, University of Iowa, Iowa City, Iowa, United States

2. Division of Hematology, Oncology, and Bone Marrow Transplantation, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States

3. Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United States

4. Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri, United States

5. Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States

Abstract

Intermittent hypoxia exposures are commonly used in physiology and many investigators use chamber systems to perform these studies. Because of the variety of chamber systems and protocols used, it is important to understand the sources of variability in intermittent hypoxia experiments that can impact reproducibility. We demonstrate sources of variability that come from the animal model, the intermittent hypoxia protocol, and the chamber system that can impact reproducibility.

Funder

American Cancer Society

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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