Increased airway liquid volumes at birth impair cardiorespiratory function in preterm and near-term lambs

Author:

Yamaoka Shigeo12,Crossley Kelly J.13,McDougall Annie R. A.13,Rodgers Karyn1,Zahra Valerie A.1,Moxham Alison1,Te Pas Arjan B.4,McGillick Erin V.13ORCID,Hooper Stuart B.13ORCID

Affiliation:

1. The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia

2. Division of Neonatology, Department of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Japan

3. The Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia

4. Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

Abstract

We provide evidence for adverse effects of elevated airway liquid volumes at birth on pulmonary blood flow and gas exchange in both preterm and near-term lambs, although the effects were greatest in near-term newborns. Our study is an important step toward understanding the fundamental physiology underlying the cardiorespiratory morbidity associated with near-term newborns with elevated airway liquid volumes leading to respiratory distress soon after birth.

Funder

Monash University

Department of Health, Australian Government | National Health and Medical Research Council

ZonMw

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Reference39 articles.

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2. Strategies for managing transient tachypnoea of the newborn - a systematic review

3. Neonatal respiratory morbidity and mode of delivery at term: influence of timing of elective caesarean section

4. Respiratory Transition in Infants Delivered by Cesarean Section

5. Transient Tachypnea of Newborn

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