Effects of time-controlled adaptive ventilation on cardiorespiratory parameters and inflammatory response in experimental emphysema-Reference-Cited by-同舟云学术

Effects of time-controlled adaptive ventilation on cardiorespiratory parameters and inflammatory response in experimental emphysema

Published:2022-02-01 Issue:2 Volume:132 Page:564-574
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Oliveira Milena Vasconcellos de¹,Magalhães Raquel Ferreira de¹,Rocha Nazareth de Novaes¹²,Fernandes Marcus Vinicius¹,Antunes Mariana Alves¹,Morales Marcelo Marcos³,Capelozzi Vera Luiza⁴,Satalin Joshua⁵,Andrews Penny⁶,Habashi Nader M.⁶,Nieman Gary⁵^ORCID,Rocco Patricia Rieken Macedo¹^ORCID,Silva Pedro Leme¹^ORCID

Affiliation:

1. Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

2. Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Rio de Janeiro, Brazil

3. Laboratory of Cellular and Molecular Physiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

4. Department of Pathology, São Paulo University, São Paulo, Brazil

5. Department of Surgery, State University of New York Upstate Medical University, Syracuse, New York

6. Department of Surgical Critical Care, R Adams Cowley Shock Trauma Center, Baltimore, Maryland

Abstract

The TCAV method reduces lung damage in ARDS. However, so far, no study has evaluated the impact of the TCAV method on ventilator-induced lung injury and cardiac function in experimental emphysema. The TCAV method at EFT/EPF ratio of 25%, compared with EFT/EPF of 75% (frequently used in ARDS), reduced lung inflammation, alveolar heterogeneity and hyperinflation, and pulmonary arterial hypertension in elastase-induced emphysema. TCAV may be a promising and personalized ventilation strategy for patients with emphysema.

Funder

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00689.2021

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