Increased peak end-expiratory pressure in ventilated preterm lambs changes cerebral microvascular perfusion: direct synchrotron microangiography assessment-Reference-Cited by-同舟云学术

Increased peak end-expiratory pressure in ventilated preterm lambs changes cerebral microvascular perfusion: direct synchrotron microangiography assessment

Published:2020-11-01 Issue:5 Volume:129 Page:1075-1084
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Inocencio Ishmael Miguel¹²,Tran Nhi Thao¹²³,Nakamura Shinji¹⁴,Khor Song J.¹²,Wiersma Manon¹²,Stoecker Katja¹²,Polglase Graeme R.¹⁵^ORCID,Pearson James T.⁶⁷^ORCID,Wong Flora Y.¹²⁸

Affiliation:

1. The Ritchie Centre, The Hudson Institute of Medical Research, Melbourne, VIC, Australia

2. Department of Paediatrics, Monash University, Melbourne, VIC, Australia

3. School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia

4. Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan

5. Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia

6. Department of Cardiac Physiology, National Cerebral and Cardiovascular Centre, Osaka, Japan

7. Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, VIC, Australia

8. Monash Newborn, Monash Medical Centre, Melbourne, VIC, Australia

Abstract

An increase of positive end-expiratory pressure (PEEP) from 5 to 10 cmH2O increased the diameter of small cerebral vessels (<150 µm) but decreased the diameter of larger cerebral vessels (>500 µm). This suggests increased intrathoracic pressure due to high PEEP can drive microvessel engorgement in the preterm brain, which may play a role in cerebrovascular injury.

Funder

Japan Society for the Promotion of Science

National Heart Foundation of Australia

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00652.2020

Reference39 articles.

1. Brain Injury in Chronically Ventilated Preterm Neonates