Reduced basal macrovascular and microvascular cerebral blood flow in young adults with metabolic syndrome: potential mechanisms-Reference-Cited by-同舟云学术

Reduced basal macrovascular and microvascular cerebral blood flow in young adults with metabolic syndrome: potential mechanisms

Published:2023-07-01 Issue:1 Volume:135 Page:94-108
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Carter Katrina J.¹^ORCID,Ward Aaron T.¹,Kellawan J. Mikhail²^ORCID,Harrell John W.³,Peltonen Garrett L.⁴,Roberts Grant S.⁵,Al-Subu Awni⁶,Hagen Scott A.⁶,Serlin Ronald C.⁷,Eldridge Marlowe W.⁶^ORCID,Wieben Oliver⁵⁸,Schrage William G.¹^ORCID

Affiliation:

1. Department of Kinesiology, University of Wisconsin, Madison, Wisconsin, United States

2. Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma, United States

3. 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, Ohio, United States

4. School of Nursing and Kinesiology, Western New Mexico University, Silver City, New Mexico, United States

5. Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, United States

6. Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States

7. Department of Educational Psychology, University of Wisconsin, Madison, Wisconsin, United States

8. Department of Radiology, University of Wisconsin, Madison, Wisconsin, United States

Abstract

We tested the impact of insulin resistance (IR) on resting cerebral blood flow (CBF) in adults with metabolic syndrome (MetSyn). Using MRI and research pharmaceuticals to study the role of NOS, ET-1, or COX signaling, we found that adults with MetSyn exhibit substantially lower CBF that is not explained by changes in NOS or ET-1 signaling. Interestingly, adults with MetSyn show a loss of COX-mediated vasodilation in the anterior but not posterior circulation.

Funder

American Diabetes Association

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | NIH Office of the Director

University of Wisconsin-Madison

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00688.2022

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