Сardiac injury in rats with experimental posttraumatic stress disorder and mechanisms of its limitation in experimental posttraumatic stress disorder-resistant rats-Reference-Cited by-同舟云学术

Сardiac injury in rats with experimental posttraumatic stress disorder and mechanisms of its limitation in experimental posttraumatic stress disorder-resistant rats

Published:2021-03-01 Issue:3 Volume:130 Page:759-771
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Manukhina Eugenia B.¹²³^ORCID,Tseilikman Vadim E.¹,Komelkova Maria V.¹,Lapshin Maxim S.¹,Goryacheva Anna V.²,Kondashevskaya Marina V.⁴,Mkhitarov Vladimir A.⁴,Lazuko Svetlana S.⁵,Tseilikman Olga B.¹⁶,Sarapultsev Alexey P.¹⁷^ORCID,Dmitrieva Yulia A.¹,Strizhikov Viktor K.⁸,Kuzhel Olga P.⁵,Downey H. Fred¹³

Affiliation:

1. School of Medical Biology, South Ural State University, Chelyabinsk, Russian Federation

2. Laboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, Moscow, Russian Federation

3. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas

4. Laboratory for Immunomorphology of Inflammation, Research Institute of Human Morphology, Moscow, Russian Federation

5. Department of Normal Physiology, Vitebsk State Medical University, Vitebsk, Republic of Belarus

6. School of Basic Medicine, Chelyabinsk State University, Chelyabinsk, Russian Federation

7. Laboratory of Immunopathophysiology, Institute of Immunology and Physiology of RAS, Ekaterinburg, Russian Federation

8. Department of Morphology and Histology, South Ural State Agricultural University, Troitsk, Russian Federation

Abstract

NEWS and NOTEWORTHY For the first time, rats exposed to stress were segregated into experimental PTSD (ePTSD)-susceptible and ePTSD-resistant rats. Cardiac injury, ECG changes, and impaired exercise tolerance were more pronounced in ePTSD-susceptible rats. Resistance to ePTSD was associated with decreased inflammation and oxidative stress and with increased protective heat shock protein 70. Results may help identify individuals at high risk of PTSD and also provide a foundation for developing preventive and therapeutic means to restrict PTSD-associated cardiac morbidity.

Funder

Russian Science Foundation

Ministry of Education and Science of the Russian Federation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00694.2019

Reference100 articles.

1. Posttraumatic stress disorder and risk for coronary heart disease: A meta-analytic review

2. Medical Comorbidity of Full and Partial Posttraumatic Stress Disorder in US Adults