A novel murine muscle loading model to investigate Achilles musculotendinous adaptation-Reference-Cited by-同舟云学术

A novel murine muscle loading model to investigate Achilles musculotendinous adaptation

Published:2021-04-01 Issue:4 Volume:130 Page:1043-1051
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Rezvani Sabah N.¹^ORCID,Nichols Anne E. C.²,Grange Robert W.³,Dahlgren Linda A.⁴^ORCID,Brolinson P. Gunnar⁵,Wang Vincent M.¹

Affiliation:

1. Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia

2. Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, New York

3. Department of Human Nutrition, Foods, and Exercise, and Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, Virginia

4. Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia

5. Edward Via College of Osteopathic Medicine, Blacksburg, Virginia

Abstract

We introduce a novel mouse model of hindlimb muscle loading designed to achieve a tissue-targeted therapeutic exercise. This innovative model allows for application of muscle loading “doses,” coupled with ankle dorsiflexion and plantarflexion, inspired by human loading clinical treatment. Our model facilitates future investigation of mechanisms whereby rehabilitative muscle loading promotes healing of Achilles tendon injuries.

Funder

HHS | National Institutes of Health

The Edward Via College of Osteopathic Medicine/Virginia-Maryland College of Veterinary Medicine Center for One Health Research Seed

Interdisciplinary Graduate Education Program in Regenerative Medicine at Virginia Tech (SNR).

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00638.2020

Reference58 articles.

1. Incidence of midportion Achilles tendinopathy in the general population