Improvement in upright and supine lung mechanics with bariatric surgery affects bronchodilator responsiveness and sleep quality

Author:

Peters Ubong1ORCID,Dechman Gail2ORCID,Hernandez Paul34,Bhatawadekar Swati5ORCID,Ellsmere James678,Maksym Geoffrey6

Affiliation:

1. Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont

2. School of Physiotherapy, Dalhousie University, Halifax, NS, Canada

3. Department of Medicine, Dalhousie University, Halifax, NS, Canada

4. Division of Respirology, Queen Elizabeth II Health Sciences Center, Halifax, NS, Canada

5. University Health Network–Toronto Rehabilitation Institute, Toronto, ON, Canada

6. School of Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

7. Department of Surgery, Dalhousie University, Halifax, NS, Canada

8. Division of General Surgery, Queen Elizabeth II Health Sciences Center, Halifax, NS, Canada

Abstract

Obesity and weight loss have complex effects on respiratory physiology, but these have been insufficiently studied, particularly at early time points following weight loss surgery and in the supine position. We evaluated 15 female participants with severe obesity before and 5 wk and 6 mo after bariatric surgery using the Pittsburgh Sleep Quality Index (PSQI), spirometry, plethysmography, and oscillometry to measure respiratory system mechanics. Oscillometry and spirometry were conducted in the upright and supine position and before and after bronchodilation with 200 µg of salbutamol. At 5 wk postsurgery, weight loss was 11.9 kg (SD 2.7) with no effect on spirometric outcomes and a slight effect on oscillometric outcomes. However, at 6 mo weight loss was 21.4 kg (SD 7.1) with a 14.1% (SD 6.1) and 17.8 (5.4)% reduction in upright and supine respiratory system resistance (Rrs),6, respectively. Respiratory system elastance also decreased by 25.7% (SD 9.4) and 20.2 (SD 7.2)% in the upright and supine positions. No changes were observed in spirometry, but sleep quality improved from PSQI of 8.4 (SD 3.5) to 4.1 (SD 2.9). Bronchodilator responsiveness was low at baseline but increased significantly after surgery, and this response was comparable to the improvement in Rrs produced by weight loss. Modeling the impedance spectra with a two-compartment model demonstrated that improvements in lung mechanics with weight loss begin in the upper or central compartment of the lungs and progress to include the peripheral compartment. Respiratory mechanics are impaired in individuals with severe obesity and is associated with poor sleep quality, but these improved substantially with weight loss. Our data provide new evidence that individuals with severe obesity may have poor sleep quality because of abnormal respiratory mechanics that weight loss improves. NEW & NOTEWORTHY This is the first study to quantify the degree of weight loss-induced improvements in respiratory system mechanics in both upright and supine positions, and its association with bronchodilator responsiveness and sleep quality at multiple time points. Weight loss induced large improvements in upright and supine respiratory system mechanics with corresponding improvements in bronchodilator responsiveness and sleep quality. Using mathematical modeling, we demonstrate that these improvements begin in the central airways and progress to include the lung periphery.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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