Multiomics profiling of the impact of an angiotensin (1–7)-expressing probiotic combined with exercise training in aged male rats-Reference-Cited by-同舟云学术

Multiomics profiling of the impact of an angiotensin (1–7)-expressing probiotic combined with exercise training in aged male rats

Published:2023-05-01 Issue:5 Volume:134 Page:1135-1153
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Baptista Liliana C.¹²³^ORCID,Zumbro Emily L.¹,Graham Zachary A.⁴⁵⁶,Hernandez Abbi R.¹,Buchanan Taylor¹,Sun Yi¹⁷,Yang YouFeng¹,Banerjee Anisha¹,Verma Amrisha⁷,Li Qiuhong⁸,Carter Christy S.¹,Buford Thomas W.¹⁹^ORCID

Affiliation:

1. Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States

2. Research Center for Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal

3. Laboratory for Integrative and Translational Research in Population Health, University of Porto, Porto, Portugal

4. Research Service, Birmingham Veterans Affair Medical Center, Birmingham, Alabama, United States

5. Healthspan, Resilience and Performance, Florida Institute for Human and Machine Cognition, Pensacola, Florida, United States

6. Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States

7. Department of Life, Health, and Physical Sciences, Gordon College, Wenham, Massachusetts, United States

8. Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States

9. Geriatric Research Education and Clinical Center, Birmingham VA Medical Center, Birmingham, Alabama, United States

Abstract

This manuscript uses a multiomics approach (i.e., microbiome, metabolomics, and transcriptomics) to explore the underlying mechanisms driven by a genetically modified probiotic (GMP) designed to express angiotensin (1–7) combined with moderate exercise training in an aged male rat model. After 12 wk of intervention, our findings suggest that our GMP enhanced gut microbial diversity while exercise training altered the transcriptional response in relevant neuroremodeling genes, inflammation, and circadian rhythm signaling pathways in an aging animal model.

Funder

Foundation for Science and Technology, Portugal

Laboratory for Integrative and Translational Research in Population Health, University of Porto

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | National Cancer Institute

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

U.S. Department of Veterans Affairs

UAB Nathan Shock Center

Publisher

American Physiological Society

Subject