PIEZO1 gain-of-function gene variant is associated with elevated tendon stiffness in humans-Reference-Cited by-同舟云学术

PIEZO1 gain-of-function gene variant is associated with elevated tendon stiffness in humans

Published:2023-07-01 Issue:1 Volume:135 Page:165-173
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Götschi Tobias¹²^ORCID,Held Victoria²³,Klucker Gianna²³,Niederöst Barbara¹²,Aagaard Per⁴,Spörri Jörg³⁴^ORCID,Passini Fabian S.¹²,Snedeker Jess G.¹²^ORCID

Affiliation:

1. Laboratory for Orthopaedic Biomechanics, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Zürich, Switzerland

2. Institute for Biomechanics, ETH Zurich, Zürich, Switzerland

3. Sports Medical Research Group, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Zürich, Switzerland

4. Department of Orthopaedics, University Centre for Prevention and Sports Medicine, Balgrist University Hospital, University of Zurich, Zürich, Switzerland

Abstract

The E756del gene variant causes overactivity of the mechanosensitive membrane channel PIEZO1 and is suspected to upregulate tendon collagen cross linking. In human carriers of E756del, we found increased patellar tendon stiffness but similar tendon lengths and cross-sectional areas, directly supporting the premise that PIEZO1 regulates human tendon stiffness at the level of tissue material properties.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00573.2022

Reference53 articles.

1. Characterizing patellar tendon loading during the landing phases of a stop-jump task

2. Tendons and Ligaments: Structure, Mechanical Behavior and Biological Function

3. The influence of tendon compliance on muscle power output and efficiency during cyclic contractions

4. Exercise-induced hyperthermia as a possible mechanism for tendon degeneration

5. Commentaries on Viewpoint: On the hysteresis in the human Achilles tendon

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