Resistance-exercise training attenuates LPS-induced astrocyte remodeling and neuroinflammatory cytokine expression in female Wistar rats-Reference-Cited by-同舟云学术

Resistance-exercise training attenuates LPS-induced astrocyte remodeling and neuroinflammatory cytokine expression in female Wistar rats

Published:2022-02-01 Issue:2 Volume:132 Page:317-326
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Kelty Taylor J.¹^ORCID,Mao Xuansong¹,Kerr Nathan R.¹,Childs Thomas E.¹,Ruegsegger Gregory N.²^ORCID,Booth Frank W.¹³⁴⁵^ORCID

Affiliation:

1. Department of Biomedical Sciences, University of Missouri, Columbia, Missouri

2. Department of Health and Human Performance, University of Wisconsin-River Falls, River Falls, Wisconsin

3. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri

4. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri

5. Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri

Abstract

To further elucidate the known cognitive health benefits from resistance-exercise training, we tested if resistance-exercise training in rats would attenuate lipopolysaccharide-induced neuroinflammation. Our data demonstrated that resistance training had an anti-inflammatory effect in the brain as LPS-induced neuroinflammatory cytokine expression and reactive astrocytic remodeling were reduced in the dentate gyrus after 3 wk of progressive ladder climbing.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00571.2021

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