Pathogenesis of obstructive sleep apnea in people living with HIV

Author:

Orr Jeremy E.1ORCID,Edwards Bradley A.23ORCID,Schmickl Christopher N.1,Karris Maile4,DeYoung Pamela N.1,Darquenne Chantal1ORCID,Theilmann Rebecca5,Jain Sonia6,Malhotra Atul1,Hicks Charles B.4,Owens Robert L.1ORCID

Affiliation:

1. Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California

2. Sleep and Circadian Medicine Laboratory, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia

3. Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia

4. Division of Infectious Disease, University of California San Diego, San Diego, California

5. Department of Radiology, University of California San Diego, San Diego, California

6. Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, California

Abstract

Clinical data suggest an increased risk of obstructive sleep apnea (OSA) in people living with HIV (PLWH), while OSA might account for chronic health issues in this population. We characterized the anatomical and nonanatomical OSA traits in PLWH + OSA compared with OSA controls, using detailed physiological measurements obtained during sleep. Our data suggest against a major impact of HIV on OSA pathogenesis. Available OSA management strategies should be effective to address this potentially important comorbidity in PLWH.

Funder

Center for AIDS Research Creative and Novel Ideas in HIV Research Program

Heart Foundation Future Leader Fellowship

HHS | NIH | National Heart, Lung, and Blood Institute

American Thoracic Society

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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