Affiliation:
1. Department of Bioengineering, Northeastern University, Boston, Massachusetts
Abstract
Targeting inflammation is the central dogma on which current asthma therapy is based. Here, we show that a healthy airway can be made to constrict excessively and at a faster rate in response to the same stimulus by increasing the stiffness of the extracellular matrix, without the use of inflammatory agents. Our results provide an independent mechanism by which airway remodeling in asthma can sustain airway hyperreactivity even in the absence of inflammatory signals.
Funder
HHS | NIH | National Heart, Lung, and Blood Institute
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
18 articles.
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