REDD1 deletion attenuates cancer cachexia in mice-Reference-Cited by-同舟云学术

REDD1 deletion attenuates cancer cachexia in mice

Published:2021-12-01 Issue:6 Volume:131 Page:1718-1730
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Hain Brian A.¹²,Xu Haifang¹,VanCleave Ashley M.¹,Gordon Bradley S.³^ORCID,Kimball Scot R.¹,Waning David L.¹²^ORCID

Affiliation:

1. Department of Cellular and Molecular Physiology, The Penn State College of Medicine, Hershey, Pennsylvania

2. Penn State Cancer Institute, Hershey, Pennsylvania

3. Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, Florida

Abstract

Cancer cachexia is a debilitating and lethal consequence of many advanced cancers. REDD1, a negative regulator of mTORC1 activity, is an emerging target in cachexia. Our data show that skeletal muscle REDD1 expression is increased in LLC-induced cancer cachexia. Mice lacking REDD1 have attenuated skeletal muscle atrophy that is likely due to maintaining both protein synthesis and inhibiting protein degradation.

Funder

Penn State Cancer Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00536.2021

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