The preponderance of initial orthostatic hypotension in postural tachycardia syndrome

Author:

Stewart Julian M.12,Kota Archana1,O’Donnell-Smith Mary Breige1,Visintainer Paul3,Terilli Courtney1,Medow Marvin S.12

Affiliation:

1. Department of Pediatric, New York Medical College, Valhalla, New York

2. Department of Physiology, New York Medical College, Valhalla, New York

3. Baystate Medical Center, University of Massachusetts School of Medicine, Springfield, Massachusetts

Abstract

Significant initial orthostatic hypotension (IOH) occurs in ~50% of postural tachycardia syndrome (POTS) patients and 13% of controls. Heart rate and blood pressure recovery are prolonged in IOH sustaining lightheadedness; IOH is more prevalent and severe in POTS. Altered cerebral blood flow and cardiorespiratory regulation are more prevalent in POTS. Altered heart rate variability and baroreflex gain may cause nearly instantaneous lightheadedness in POTS. IOH alone fails to confer a strong probability of POTS.

Funder

National Heart Lung and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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