Acute interleukin-6 modulates key enzymes involved in prefrontal cortex and hippocampal amyloid precursor protein processing-Reference-Cited by-同舟云学术

Acute interleukin-6 modulates key enzymes involved in prefrontal cortex and hippocampal amyloid precursor protein processing

Published:2023-05-01 Issue:5 Volume:134 Page:1115-1123
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Marko Daniel M.¹^ORCID,Finch Michael S.¹^ORCID,Yang Alex J. T.¹,Castellani Laura N.²,Peppler Willem T.²,Wright David C.³⁴⁵^ORCID,MacPherson Rebecca E. K.¹⁶^ORCID

Affiliation:

1. Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada

2. Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

3. School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada

4. Faculty of Land and Food Systems, University of British Columbia, Vancouver, British Columbia, Canada

5. BC Children’s Hospital Research Institute, Vancouver, British Columbia, Canada

6. Centre for Neuroscience, Brock University, St. Catharines, Ontario, Canada

Abstract

It is becoming evident that exercise modulates APP processing and can reduce amyloid-beta (Aβ) peptide production. Our data help to explain this phenomenon by highlighting IL-6 as an exercise-induced factor that lowers pathological APP processing. These results also highlight brain regional differences in response to acute IL-6.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00520.2022

Reference52 articles.

1. An Overview of APP Processing Enzymes and Products

2. APP processing: a biochemical competition influenced by exercise-induced signaling mediators?

3. Amyloid beta 42 oligomers induce neuronal and synaptic receptor dysfunctions

4. Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease

5. Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice

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