Optimization of a pericyte therapy to improve muscle recovery after limb immobilization-Reference-Cited by-同舟云学术

Optimization of a pericyte therapy to improve muscle recovery after limb immobilization

Published:2022-04-01 Issue:4 Volume:132 Page:1020-1030
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Wu Yu-Fu¹²,Lapp Samuel¹²,Dvoretskiy Svyatoslav¹²,Garcia Gabriela¹²,Kim Michael²,Tannehill Amanda²,Daniels Laureen²³,Boppart Marni D.¹²³^ORCID

Affiliation:

1. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, Illinois

2. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, Illinois

3. Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Champaign, Illinois

Abstract

In this study, pericytes were isolated from mouse skeletal muscle based on cell surface marker expression of neural/glial antigen 2 (NG2) or melanoma cell adhesion molecule (Mcam/CD146) and then compared for the capacity to recover skeletal muscle after a period of immobilization in recipient mice. We report that CD146+Lin− pericytes exhibit higher capacity than NG2+Lin− pericytes to recover Type IIa fiber quantity, capillary content, and collagen turnover after disuse.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00700.2021

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