Quantitative CT image-based structural and functional changes during asthma acute exacerbations

Author:

Park Joonwoo1,Kim Sujeong2ORCID,Lim Jae-Kwang3,Jin Kwang Nam4,Yang Min Suk5,Chae Kum Ju6,Jin Gong Yong6,Kim Tae-Bum7,Kim Hee-Kyoo8,Lee Kyeong Eun9,Lee Chang Hyun10,Choi Sanghun1ORCID

Affiliation:

1. School of Mechanical Engineering, College of Engineering, Kyungpook National University, Daegu, South Korea

2. Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea

3. Department of Radiology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea

4. Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea

5. Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea

6. Department of Radiology, Institute of Medical Science, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea

7. Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

8. Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, South Korea

9. Department of Statistics, College of Natural Sciences, Kyungpook National University, Daegu, South Korea

10. Department of Radiology, College of Medicine, Seoul National University, Seoul National University Hospital, Seoul, South Korea

Abstract

Using two sets of inspiration and expiration images, the difference of segmental airway structure and parenchymal lung function is assessed by comparing the QCT images during asthma acute exacerbations with those in stable asthma. This study also introduces a useful application of an imaging-based metric, estimating the heterogeneity of tissue distribution. This could be a phenotype for the asthma acute exacerbation.

Funder

Ministry of Environment

National Research Foundation of Korea

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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