Sex-specific effects of cardiorespiratory fitness on age-related differences in cerebral hemodynamics-Reference-Cited by-同舟云学术

Sex-specific effects of cardiorespiratory fitness on age-related differences in cerebral hemodynamics

Published:2022-05-01 Issue:5 Volume:132 Page:1310-1317
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Zeller Niklaus P.¹,Miller Kathleen B.¹^ORCID,Zea Ryan D.¹,Howery Anna J.¹,Labrecque Lawrence²³,Aaron Stacey E.⁴^ORCID,Brassard Patrice²³^ORCID,Billinger Sandra A.⁴⁵^ORCID,Barnes Jill N.¹^ORCID

Affiliation:

1. Bruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin

2. Department of Kinesiology, Faculty of Medicine, Université Laval, Quebec City, Québec, Canada

3. Research Center of the Institut, Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Québec, Canada

4. Department of Physical Therapy, Rehabilitation Science and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas

5. University of Kansas Alzheimer’s Disease Research Center, Fairway, Kansas

Abstract

We present data pooled from three institutions to study the impact of age, sex, and cardiorespiratory fitness on cerebral hemodynamics. Cardiorespiratory fitness was positively associated with middle cerebral artery blood velocity in women, but not in men. Furthermore, cardiorespiratory fitness was inversely associated with cerebral pulsatility index in both men and women, which remained significant in women when adjusting for age. These data suggest a sex-specific impact of cardiorespiratory fitness on resting cerebral hemodynamics.

Funder

Wohlgemuth Faculty Scholar Award, University of Kansas

Landon Center on Aging, University of Kansas Medical Center

American Heart Association

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

Ministère de l'Éducation, du Loisir et du Sport Québec

UL | Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval

University of Wisconsin-Madison

Wisconsin Alumni Research Foundation