Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension-Reference-Cited by-同舟云学术

Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension

Published:2023-10-01 Issue:4 Volume:135 Page:717-725
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Shoemaker Leena N.¹²³^ORCID,Milej Daniel¹²^ORCID,Sajid Aleena³^ORCID,Mistry Jigneshkumar¹²,Lawrence Keith St¹²^ORCID,Shoemaker J. Kevin³⁴^ORCID

Affiliation:

1. Imaging Program, Lawson Health Research Institute, London, Ontario, Canada

2. Department of Medical Biophysics, Western University, London, Ontario, Canada

3. School of Kinesiology, Western University, London, Ontario, Canada

4. Department of Physiology and Pharmacology, Western University, London, Ontario, Canada

Abstract

To characterize the relationship between cerebrovascular patterns within the large middle cerebral artery (MCA) and a downstream microvascular segment, we used a novel combination of transcranial Doppler ultrasound of the MCA and optical monitoring of a downstream microvascular segment, respectively, under conditions of transiently reduced mean arterial pressure (i.e., lower body negative pressure, −80 mmHg). A rapid increase in vessel compliance accompanied the maintenance of MCA blood velocity and downstream microvascular flow.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00743.2022

Reference42 articles.

1. Reactivity of larger intracranial arteries using 7 T MRI in young adults

2. Regulation of large cerebral arteries and cerebral microvascular pressure.