Serial changes in nasal potential difference and lung electrical impedance tomography at high altitude

Author:

Mason Nicholas P.1,Petersen Merete2,Mélot Christian3,Imanow Bakyt4,Matveykine Olga4,Gautier Marie-Therese1,Sarybaev Akpay4,Aldashev Almaz4,Mirrakhimov Mirsaid M.4,Brown Brian H.5,Leathard Andrew D.5,Naeije Robert1

Affiliation:

1. Department of Physiology, Free University of Brussels, B1070 Brussels, Belgium;

2. Faculty of Health Sciences, University of Copenhagen, DK-2000 Copenhagen N, Denmark;

3. Department of Intensive Care Medicine, Erasme Hôspital, B1070 Brussels, Belgium;

4. National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan;

5. Department of Medical Physics, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom

Abstract

Recent work suggests that treatment with inhaled β2-agonists reduces the incidence of high-altitude pulmonary edema in susceptible subjects by increasing respiratory epithelial sodium transport. We estimated respiratory epithelial ion transport by transepithelial nasal potential difference (NPD) measurements in 20 normal male subjects before, during, and after a stay at 3,800 m. NPD hyperpolarized on ascent to 3,800 m ( P < 0.05), but the change in potential difference with superperfusion of amiloride or isoprenaline was unaffected. Vital capacity (VC) fell on ascent to 3,800 m ( P < 0.05), as did the normalized change in electrical impedance (NCI) measured over the right lung parenchyma ( P < 0.05) suggestive of an increase in extravascular lung water. Echo-Doppler-estimated pulmonary artery pressure increases were insufficient to cause clinical pulmonary edema. There was a positive correlation between VC and NCI ( R 2 = 0.633) and between NPD and both VC and NCI ( R 2 = 0.267 and 0.418). These changes suggest that altered respiratory epithelial ion transport might play a role in the development of subclinical pulmonary edema at high altitude in normal subjects.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 44 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3