Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer’s disease of 3×Tg mice-Reference-Cited by-同舟云学术

Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer’s disease of 3×Tg mice

Published:2022-04-01 Issue:4 Volume:132 Page:1054-1068
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Park Sang-Seo¹,Park Hye-Sang²,Kim Chang-Ju²^ORCID,Baek Seung-Soo³^ORCID,Park Song-Young¹^ORCID,Anderson Cody¹,Kim Myung-Ki⁴,Park Ik-Ryeul⁵,Kim Tae-Woon⁵

Affiliation:

1. School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, Nebraska

2. Department of Physiology, College of Medicine, KyungHee University, Seoul, Republic of Korea

3. Department of Exercise & Health Science, Sangmyung University, Seoul, Republic of Korea

4. Division of Global Sport Studies, Korea University, Sejong, Republic of Korea

5. Department of Human Health Care, Gyeongsang National University, Jinju, Republic of Korea

Abstract

Exercising in a 40-Hz light flicker environment was more effective than exercise or 40-Hz light flicker alone. This synergistic effect may prevent cognitive dysfunction by inhibiting Aβ, tau pathway, and neuroinflammation and enhancing neuroplasticity and mitochondrial functions in the hippocampus during early Alzheimer’s disease.

Funder

Ministry of Education

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00751.2021

Reference96 articles.

1. Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

2. Alzheimer's Disease: The Amyloid Cascade Hypothesis

3. The amyloid cascade hypothesis: are we poised for success or failure?