Exogenous ketosis increases circulating dopamine concentration and maintains mental alertness in ultra-endurance exercise-Reference-Cited by-同舟云学术

Exogenous ketosis increases circulating dopamine concentration and maintains mental alertness in ultra-endurance exercise

Published:2023-06-01 Issue:6 Volume:134 Page:1456-1469
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Poffé Chiel¹^ORCID,Robberechts Ruben¹^ORCID,Stalmans Myrthe¹,Vanderroost Jan²,Bogaerts Stijn³⁴,Hespel Peter⁵^ORCID

Affiliation:

1. Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium

2. Bakala Academy-Athletic Performance Center, KU Leuven, Leuven, Belgium

3. Department of Physical and Rehabilitation Medicine, University Hospitals Leuven, Leuven, Belgium

4. Locomotor and Neurological Disorders, Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Leuven, Belgium

5. Department of Movement Sciences, KU Leuven, Leuven, Belgium

Abstract

Oral ketone ester ingestion elevates circulating dopamine concentration during ultra-endurance exercise. This is associated with improved mental alertness. Furthermore, ketone ester intake inhibits postexercise skeletal muscle macrophage infiltration, and counteracts the increase in AMPK phosphorylation after exercise, which indicates improved muscular energy status.

Funder

Vlaamse Overheid

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00791.2022

Reference51 articles.

1. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

2. Acute nutritional ketosis: implications for exercise performance and metabolism

3. Skeletal muscle energy metabolism during exercise