Sex and diet, but not exercise, alter cardiovascular ACE2 and TMPRSS2 mRNA levels in aortic banded swine-Reference-Cited by-同舟云学术

Sex and diet, but not exercise, alter cardiovascular ACE2 and TMPRSS2 mRNA levels in aortic banded swine

Published:2023-02-01 Issue:2 Volume:134 Page:482-489
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Kelly Shannon C.¹²,Thorne Pamela K.¹²,Leary Emily V.³^ORCID,Emter Craig A.¹²^ORCID

Affiliation:

1. Department of Biomedical Sciences, University of Missouri, Columbia, Missouri

2. NextGen Precision Health Institute, University of Missouri, Columbia, Missouri

3. Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri

Abstract

This retrospective analysis evaluated the impact of exercise, sex, and diet on ACE2 and TMPRSS2 mRNA levels in preclinical swine heart failure models. Unlike normal exercise intensities, exercise training of an intensity tolerable to a patient with heart failure had no influence on ACE2 or TMPRSS2 mRNA. In a tissue-specific manner, ACE2 mRNA levels were altered due to sex and Western diet, whereas TMPRSS2 mRNA levels were sensitive to sex, Western diet, and pig species.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00736.2022

Reference41 articles.

1. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

2. A pneumonia outbreak associated with a new coronavirus of probable bat origin

3. Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects

4. Mechanisms of SARS-CoV-2 Transmission and Pathogenesis