The left ventricle increases contractility in response to baroreceptor unloading, which is sympathetically mediated in the anesthetized rat

Author:

Stewart Liam C.1234,Wainman Liisa1234,Ahmadian Mehdi1254ORCID,Duffy Jennifer1234,Seethaler Rudolph6,Mueller Patrick J.7ORCID,Eves Neil D.28ORCID,West Christopher R.1234ORCID

Affiliation:

1. Centre for Chronic Disease Prevention and Management, University of British Columbia, Kelowna, British Columbia, Canada

2. Centre for Heart, Lung & Vascular Health, University of British Columbia, Kelowna, British Columbia, Canada

3. Faculty of Medicine, Department of Cellular & Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

4. International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada

5. Faculty of Education, School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada

6. School of Engineering, University of British Columbia Okanagan, Kelowna, British Columbia, Canada

7. Department of Physiology, School of Medicine, Wayne State University, Detroit, Michigan, United States

8. Faculty of Health and Social Development, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada

Abstract

This study empirically demonstrates a sympathetically mediated increase in LV contractility in response to baroreceptor unloading using a load-independent index of cardiac contractility in the anesthetized rat.

Funder

Canadian Government | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

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