Low noncarbonic buffer power amplifies acute respiratory acid-base disorders in patients with sepsis: an in vitro study-Reference-Cited by-同舟云学术

Low noncarbonic buffer power amplifies acute respiratory acid-base disorders in patients with sepsis: an in vitro study

Published:2021-08-01 Issue:2 Volume:131 Page:464-473
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Langer Thomas¹²^ORCID,Brusatori Serena³,Carlesso Eleonora³,Zadek Francesco³,Brambilla Paolo³,Ferraris Fusarini Chiara⁴,Duska Frantisek⁵,Caironi Pietro⁶⁷,Gattinoni Luciano⁸^ORCID,Fasano Mauro⁹,Lualdi Marta⁹,Alberio Tiziana⁹,Zanella Alberto³¹⁰,Pesenti Antonio³¹⁰,Grasselli Giacomo³¹⁰

Affiliation:

1. Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy

2. Department of Anesthesia and Intensive Care Medicine, Niguarda Ca' Granda, Milan, Italy

3. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

4. Clinical Laboratory, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy

5. Department of Anaesthesia and Intensive Care Medicine, The Third Faculty of Medicine, Charles University and FNKV University Hospital, Prague, Czech Republic

6. Department of Anesthesia and Critical Care, Azienda Ospedaliero-Universitaria S. Luigi Gonzaga, Orbassano, Italy

7. Department of Oncology, University of Turin, Orbassano, Italy

8. Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany

9. Department of Science and High Technology, University of Insubria, Busto Arsizio, Italy

10. Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Abstract

Patients with sepsis are poorly protected against acute respiratory acid-base derangements due to a lower noncarbonic buffer power, which is caused both by a reduction in the major noncarbonic buffers, i.e. hemoglobin and albumin, and by a reduced buffering capacity of albumin. Electrolyte shifts from and to the red blood cells determining acute variations in strong ion difference are the major buffering mechanism during acute respiratory acid-base disorders.

Funder

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00787.2020

Reference59 articles.

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