Treadmill running increases the calcium sensitivity of myofilaments in diabetic rats-Reference-Cited by-同舟云学术

Treadmill running increases the calcium sensitivity of myofilaments in diabetic rats

Published:2022-06-01 Issue:6 Volume:132 Page:1350-1360
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Greenman Angela C.¹²³^ORCID,Diffee Gary M.⁴,Power Amelia S.²³,Wilkins Gerard T.¹³,Gold Olivia M. S.²³,Erickson Jeffrey R.²³^ORCID,Baldi James C.¹³^ORCID

Affiliation:

1. Department of Medicine, Otago Medical School, University of Otago, Dunedin, New Zealand

2. Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

3. HeartOtago, University of Otago, Dunedin, New Zealand

4. Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin

Abstract

We examined the effects of training on the myofilament calcium in diabetic rat hearts. After 8 wk of treadmill running, both nondiabetic and diabetic cardiomyocytes had increased myofilament calcium sensitivity compared with their sedentary counterparts, but there was no effect of training on the phosphorylation or O-GlcNAcylation status of myofilament proteins measured in this study. These data highlight one potential mechanism capable of reversing, in part, reduced cardiac reserve in the diabetic heart.

Funder

Southland Medical Foundation

Manatu Hauora | Health Research Council of New Zealand

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00785.2021

Reference71 articles.

1. Effects of exercise training on oxygen uptake kinetic responses in women with type 2 diabetes.

2. Skeletal Muscle Deoxygenation After the Onset of Moderate Exercise Suggests Slowed Microvascular Blood Flow Kinetics in Type 2 Diabetes