The effect of inhaled nitric oxide on maximal oxygen consumption during exercise in acute hypoxia: a randomized double-blind crossover trial-Reference-Cited by-同舟云学术

The effect of inhaled nitric oxide on maximal oxygen consumption during exercise in acute hypoxia: a randomized double-blind crossover trial

Published:2024-03-01 Issue:3 Volume:136 Page:514-524
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Rampuri Zahrah H.¹²,Collins Sophie É.¹²^ORCID,Mickelsen Benjamin S.A¹³,Brotto Andrew R.¹³,Beaudry Rhys I.¹,van Diepen Sean⁴,Stickland Michael K.¹⁵^ORCID

Affiliation:

1. Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

2. Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada

3. Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada

4. Department of Critical Care and Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

5. G.F. MacDonald Centre for Lung Health, Covenant Health, Edmonton, Alberta, Canada

Abstract

The elevation of pulmonary artery pressure (PAP) with hypoxia may impair peak cardiac output ([Formula: see text]) and therefore V̇o2max. Our novel findings show that despite reducing resting RVSP in acute moderate ([Formula: see text] = 89 mmHg) and severe hypoxia ([Formula: see text] = 79 mmHg) with inspired nitric oxide, peak [Formula: see text], and V̇o2max were unaffected.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00767.2022

Reference42 articles.

1. Operation Everest II and the 1978 Habeler/Messner ascent of Everest without bottled O2: what might they have in common?

2. Submaximal exercise testing at low altitude for prediction of exercise tolerance at high altitude

3. Increased arterial desaturation in trained cyclists during maximal exercise at 580 m altitude

4. Hemodynamic response to work at simulated altitude, 4,000 m.

5. Operation Everest II: preservation of cardiac function at extreme altitude