An interventional sheep model of severe aortic valve stenosis hemodynamics for the evaluation of alterations in coronary physiology and microvascular function-Reference-Cited by-同舟云学术

An interventional sheep model of severe aortic valve stenosis hemodynamics for the evaluation of alterations in coronary physiology and microvascular function

Published:2024-03-01 Issue:3 Volume:136 Page:606-617
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Minten Lennert¹²^ORCID,Langenaeken Tom¹³,McCutcheon Keir¹,Bennett Johan¹²^ORCID,Van Hecke Manon⁴,Algoet Michiel¹³,Bézy Stéphanie¹,Duchenne Jürgen¹,Puvrez Alexis¹,Wouters Laurine¹,Voigt Jens-Uwe¹²,Adriaenssens Tom¹²,Desmet Walter¹²,Sinnaeve Peter¹²^ORCID,Verbrugghe Peter¹³,Oosterlinck Wouter¹³,Claus Piet¹^ORCID,Meuris Bart¹³,Dubois Christophe¹²

Affiliation:

1. Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

2. Department of Cardiovascular Medicine, University Hospitals Leuven (UZ Leuven), Leuven, Belgium

3. Department of Cardiac Surgery, University Hospitals Leuven (UZ Leuven), Leuven, Belgium

4. Department of Imaging and Pathology, KU Leuven, Leuven, Belgium

Abstract

In an animal model of aortic valve stenosis (AS), coronary physiological changes are characterized by increased resting coronary flow and hyperemic coronary resistance. These changes can impact coronary indices frequently used to assess concomitant coronary artery disease (CAD). At this point, the best way to assess and treat CAD in AS remains unclear. Our data suggest that fractional flow reserve may underestimate CAD, and nonhyperemic pressure ratios may overestimate CAD severity before aortic valve replacement.

Funder

Belgian Fund for Heart Surgery

Fonds Wetenschappelijk Onderzoek

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00737.2023

Reference48 articles.

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5. Coronary microvascular dysfunction: an update

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