Effects of comorbid type II diabetes mellitus and heart failure on rat hindlimb and respiratory muscle blood flow during treadmill exercise

Author:

Butenas Alec L. E.1ORCID,Copp Steven W.1ORCID,Hageman K. Sue2,Poole David C.12ORCID,Musch Timothy I.12ORCID

Affiliation:

1. Department of Kinesiology, Kansas State University, Manhattan, Kansas, United States

2. Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States

Abstract

Herein, we demonstrate that rats comorbid with heart failure with reduced ejection fraction (HF-rEF) and type II diabetes mellitus (T2DM) have a higher hindlimb and respiratory muscle blood flow during submaximal treadmill running (20 m·min−1; 10% incline) compared with nondiabetic HF-rEF counterparts. These data may carry important clinical implications for roughly half of all patients with HF-rEF who present with T2DM.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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