Effects of metabolic syndrome on fuel utilization during exercise in middle-aged moderately trained individuals

Abstract

We hypothesized that the metabolic disarrangements of individuals suffering metabolic syndrome (i.e., obesity, insulin resistance and dyslipidemia) may blunt substrate utilization during exercise. Using tracer techniques, we observed that at moderate-and-high exercise intensity, whole body lipolysis and plasma glucose metabolic clearance rate are limited in individuals with metabolic syndrome. However, the metabolic syndrome, did not limit endogenous carbohydrate (Ra glucose) and fat (Ra glycerol) mobilization, or fat oxidation during exercise of low intensity. Our data suggest that suffering from metabolic syndrome does not limit fat oxidation during low-intensity exercise.