The proteomic response is linked to regional lung volumes in ventilator-induced lung injury-Reference-Cited by-同舟云学术

The proteomic response is linked to regional lung volumes in ventilator-induced lung injury

Published:2020-10-01 Issue:4 Volume:129 Page:837-845
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Yen Seiha¹^ORCID,Song Yong²^ORCID,Preissner Melissa³,Bennett Ellen¹,Wilson Richard⁴,Pavez Macarena²,Dubsky Stephen³,Dargaville Peter A.²,Fouras Andreas⁵,Zosky Graeme R.¹²^ORCID

Affiliation:

1. School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia

2. Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia

3. Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, Victoria, Australia

4. Central Science Laboratory, University of Tasmania, Hobart, Tasmania, Australia

5. 4Dx Limited, Melbourne, Victoria, Australia

Abstract

This study provides novel insights into the regional response to mechanical ventilation in the setting of acid-induced lung injury and highlights the complex interaction between tidal stretch and low end-expiratory lung volumes; both of which caused altered regulation of different injury pathways.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Royal Hobart Hospital Foundation

Multi-model Australia ScienceS Imaging

ARC

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00097.2020

Reference37 articles.