Sex differences in spontaneous respiratory recovery following chronic C2 hemisection-Reference-Cited by-同舟云学术

Sex differences in spontaneous respiratory recovery following chronic C2 hemisection

Published:2024-07-01 Issue:1 Volume:137 Page:166-180
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Holmes Taylor C.¹,Popp Nicole M.¹,Hintz Carley F.¹,Dobrzycki Isabell¹²,Schmitz Carolyn J.¹,Schwichtenberg Kaylyn A.¹,Gonzalez-Rothi Elisa J.³^ORCID,Sundberg Christopher W.¹²^ORCID,Streeter Kristi A.¹^ORCID

Affiliation:

1. Exercise and Rehabilitation Science Program, Department of Physical Therapy, Marquette University, Milwaukee, Wisconsin, United States

2. Athletic and Human Performance Research Center, Marquette University, Milwaukee, Wisconsin, United States

3. Department of Physical Therapy, University of Florida, Gainesville, Florida, United States

Abstract

In response to chronic C2 hemisection, female rodents display increased tidal volume during eupneic breathing compared with males. Females show a greater reduction in diaphragm electromyography (EMG) amplitude during spontaneous deep breaths (e.g., sighs) and atrophy and remodeling of fast, fatigable diaphragm fibers. Given that most rehabilitative interventions occur in the subacute to chronic stages of injury, these results highlight the importance of considering sex when developing and evaluating therapeutics after spinal cord injury.

Funder

Craig H. Neilsen Foundation

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00040.2024

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