Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats-Reference-Cited by-同舟云学术

Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats

Published:2022-08-01 Issue:2 Volume:133 Page:371-389
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Biancardi Vivian¹²^ORCID,Patrone Luis Gustavo A.¹,Vicente Mariane C.¹,Marques Danuzia A.¹³^ORCID,Bícego Kênia C.¹^ORCID,Funk Gregory D.²,Gargaglioni Luciane H.¹^ORCID

Affiliation:

1. Department of Animal Morphology and Physiology, Sao Paulo State University—UNESP/FCAV, Jaboticabal, Brazil

2. Department of Physiology, Faculty of Medicine and Dentistry, Women and Children’s Health Research Institute, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada

3. Department of Pediatrics, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada

Abstract

Selective serotonin reuptake inhibitors (SSRIs) readily cross the placental and the fetal blood-brain barrier where it will affect 5-HT levels in the developing brain. Although SSRI is used during pregnancy, there are no studies showing SSRI exposure during late pregnancy and postnatal effects on breathing control in males and females. We demonstrated that fluoxetine exposure during late pregnancy in rats was associated with long-lasting, sex-specific effects on breathing and brainstem monoaminergic groups.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Gouvernement du Canada | Canadian Institutes of Health Research

Women and Children's Health Research Institute

Stollery Children's Hospital Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00020.2022