Repeated seizures lead to progressive ventilatory dysfunction in SS<i><sup>Kcnj16−/−</sup></i> rats-Reference-Cited by-同舟云学术

Repeated seizures lead to progressive ventilatory dysfunction in SS^{Kcnj16−/−} rats

Published:2023-10-01 Issue:4 Volume:135 Page:872-885
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Manis Anna D.¹^ORCID,Cook-Snyder Denise R.¹,Duffy Erin¹,Osmani Wasif A.¹,Eilbes Melissa¹,Dillard Matthew¹,Palygin Oleg¹²^ORCID,Staruschenko Alexander¹³⁴^ORCID,Hodges Matthew R.¹⁵^ORCID

Affiliation:

1. Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States

2. Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States

3. Department of Molecular Pharmacology & Physiology, University of South Florida, Tampa, Florida, United States

4. James A. Haley Veterans’ Hospital, Tampa, Florida, United States

5. Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Abstract

This study demonstrated that repeated seizures in a novel rat model (SS Kcnj16−/− rats) caused a progressively greater ventilatory dysfunction in the immediate postictal period associated with brainstem serotonin (5-HT) suppression. Augmenting brain 5-HT with a selective serotonin reuptake inhibitor prevented the progressive ventilatory dysfunction induced by repeated seizures but failed to prevent seizure-related mortality, suggesting that repeated seizures may lead to cardiorespiratory suppression and failure through multiple mechanisms.

Funder

SC SmartState Centers of Excellence

anonymous foundation donation

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00072.2023

Reference65 articles.