MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation-Reference-Cited by-同舟云学术

MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation

Published:2022-12-01 Issue:6 Volume:133 Page:1349-1355
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Sater Stuart H.¹^ORCID,Conley Natividad Gabryel¹,Seiner Akari J.²,Fu Audrey Q.³,Shrestha Dev²,Bershad Eric M.⁴,Marshall-Goebel Karina⁵^ORCID,Laurie Steven S.⁵^ORCID,Macias Brandon R.⁶^ORCID,Martin Bryn A.¹²^ORCID

Affiliation:

1. Alcyone Therapeutics Inc., Lowell, Massachusetts

2. Department of Chemical and Biological Engineering, University of Idaho, Moscow, Idaho

3. Department of Mathematics and Statistical Science, Institute of Bioinformatics and Evolutionary Studies, Institute for Modeling Collaboration & Innovation, University of Idaho, Moscow, Idaho

4. Department of Neurology, Baylor College of Medicine, Houston, Texas

5. KBR, Houston, Texas

6. Cardiovascular and Vision Laboratory, Johnson Space Center, National Aeronautics and Space Administration, Houston, Texas

Abstract

Head-down tilt (HDT) bed rest is commonly used as a spaceflight analog for investigating spaceflight associated neuro-ocular syndrome (SANS). Posterior ocular globe flattening has been identified in astronauts with SANS but until now has not been investigated during HDT bed rest. In this study, posterior ocular globe volume displacement was quantified before, during, and after HDT bed rest and countermeasures were tested for their potential to reduce the degree of globe flattening.

Funder

NASA | Johnson Space Center

NASA Idaho Space Grant Consortium

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00082.2022

Reference21 articles.

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5. Stenger MB, Tarver WJ, Brunstetter T, Gibson CR, Laurie SS, Lee SMC, Macias BR, Mader TH, Otto C, Smith SM, Zwart SR. Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS). Houston, TX: National Aeronautics and Space Administration, Lyndon B. Johnson Space Center, 2017.

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