Balance between oxygen transport and blood rheology during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-Reference-Cited by-同舟云学术

Balance between oxygen transport and blood rheology during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin

Published:2020-07-01 Issue:1 Volume:129 Page:97-107
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Williams Alexander T.¹^ORCID,Lucas Alfredo¹,Muller Cynthia R.¹,Bolden-Rush Crystal²,Palmer Andre F.²,Cabrales Pedro¹

Affiliation:

1. Department of Bioengineering, University of California, San Diego, La Jolla, California

2. William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio

Abstract

Large-molecular diameter polymerized bovine hemoglobin avoided vasoconstriction and impairment of cardiac function during resuscitation from hemorrhagic shock that was seen with previous hemoglobin-based O2 carriers by increasing blood viscosity in a concentration-dependent manner. Supplementation of O2-carrying capacity played a smaller role in maintaining cardiac function than increased blood and plasma viscosity.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00016.2020

Reference33 articles.

1. Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic

2. Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins

3. EARLY DIFFERENCE IN TISSUE PH AND MICROVASCULAR HEMODYNAMICS IN HEMORRHAGIC SHOCK RESUSCITATION USING POLYETHYLENE GLYCOL-ALBUMIN- AND HYDROXYETHYL STARCH-BASED PLASMA EXPANDERS

4. Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions

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