Ventilation heterogeneity in smokers: role of unequal lung expansion and peripheral lung structure-Reference-Cited by-同舟云学术

Ventilation heterogeneity in smokers: role of unequal lung expansion and peripheral lung structure

Published:2020-09-01 Issue:3 Volume:129 Page:583-590
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Verbanck Sylvia A.B.¹^ORCID,Polfliet Mathias²³⁴,Schuermans Daniel¹,Ilsen Bart⁵,de Mey Johan⁵,Vanderhelst Eef¹,Vandemeulebroucke Jef²³

Affiliation:

1. Respiratory Division, University Hospital (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium

2. Department of Electronics and Informatics (ETRO), Vrije Universiteit Brussel (VUB), Brussels, Belgium

3. Imec, Kapeldreef, Leuven, Belgium

4. Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands

5. Department of Radiology, University Hospital (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium

Abstract

A head-on comparison between imaging and multiple breath washout in supine smokers shows that computer tomography-measured unequal local lung expansion accounts for 50% or less of smoking-induced increase in ventilation heterogeneity. The contributions from unequal lung expansion and peripheral structure to the two main washout indices also explain their respective association with parametric response mapping indices.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00105.2020

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