Improving pulmonary perfusion assessment by dynamic contrast-enhanced computed tomography in an experimental lung injury model

Author:

Xin Yi12,Kim Taehwan1,Winkler Tilo12ORCID,Brix Gunnar3ORCID,Gaulton Timothy12ORCID,Gerard Sarah E.4,Herrmann Jacob4ORCID,Martin Kevin T.1,Victor Marcus56ORCID,Reutlinger Kristan7,Amato Marcelo5,Berra Lorenzo12,Kalra Mannudeep K.89,Cereda Maurizio12ORCID

Affiliation:

1. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States

2. Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Boston, Massachusetts, United States

3. Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Salzgitter, Germany

4. Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States

5. Disciplina de Pneumologia, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

6. Electronics Engineering Division, Aeronautics Institute of Technology, Sao Paulo, Brazil

7. Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States

8. Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States

9. Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States

Abstract

Dynamic contrast-enhanced CT using a lower-viscosity contrast agent in combination with tracer-kinetic analysis by the steepest-slope model improves pulmonary blood flow measurements and assessment of regional distributions of lung perfusion.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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