Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol-Reference-Cited by-同舟云学术

Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol

Published:2024-09-01 Issue:3 Volume:137 Page:473-493
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

,Jakicic John M.¹^ORCID,Kohrt Wendy M.²,Houmard Joseph A.³^ORCID,Miller Michael E.⁴,Radom-Aizik Shlomit⁵^ORCID,Rasmussen Blake B.⁶^ORCID,Ravussin Eric⁷,Serra Monica⁶,Stowe Cynthia L.⁸^ORCID,Trappe Scott⁹^ORCID,Abouassi Hiba¹⁰,Adkins Joshua N.¹¹,Alekel D. Lee¹²,Ashley Euan¹³^ORCID,Bamman Marcas M.¹⁴^ORCID,Bergman Bryan C.²^ORCID,Bessesen Daniel H.²,Broskey Nicholas T.³^ORCID,Buford Thomas W.¹⁴^ORCID,Burant Charles F.¹⁵^ORCID,Chen Haiying⁴,Christle Jeffrey W.¹³,Clish Clary B.¹⁶^ORCID,Coen Paul M.¹⁷,Collier David³,Collins Katherine A.¹⁰,Cooper Daniel M.⁵^ORCID,Cortes Tiffany⁶,Cutter Gary R.¹⁸,Dubis Gabriel³,Fernández Facundo M.¹⁹,Firnhaber Jonathon³,Forman Daniel E.²⁰,Gaul David A.¹⁹,Gay Nicole²¹^ORCID,Gerszten Robert E.¹⁶²²,Goodpaster Bret H.¹⁷,Gritsenko Marina A.¹¹,Haddad Fadia⁵,Huffman Kim M.¹⁰,Ilkayeva Olga²³,Jankowski Catherine M.²,Jin Christopher²¹,Johannsen Neil M.⁷,Johnson Johanna¹⁰^ORCID,Kelly Leslie¹⁰,Kershaw Erin²⁰,Kraus William E.⁴^ORCID,Laughlin Maren²⁴,Lester Bridget⁹,Lindholm Malene E.¹³,Lowe Adam⁷,Lu Ching-Ju²⁵,McGowan Joan¹²,Melanson Edward L.²^ORCID,Montgomery Stephen²⁶,Moore Samuel G.¹⁹,Moreau Kerrie L.²^ORCID,Muehlbauer Michael²³,Musi Nicolas²⁷,Nair Venugopalan D.²⁸,Newgard Christopher B.²³,Newman Anne B.²⁰,Nicklas Barbara⁴,Nindl Bradley C.²⁰,Ormond Kelly¹³²⁹,Piehowski Paul D.¹¹,Qian Wei-Jun¹¹^ORCID,Rankinen Tuomo⁷,Rejeski W. Jack³⁰,Robbins Jeremy²²,Rogers Renee J.¹,Rooney Jessica L.³¹,Rushing Scott⁴,Sanford James A.¹¹,Schauer Irene E.²^ORCID,Schwartz Robert S.²,Sealfon Stuart C.²⁸,Slentz Cris¹⁰,Sloan Ruben³,Smith Kevin S.²⁶,Snyder Michael²¹^ORCID,Spahn Jessica³²,Sparks Lauren M.¹⁷^ORCID,Stefanovic-Racic Maja²⁰^ORCID,Tanner Charles J.³,Thalacker-Mercer Anna¹⁴,Tracy Russell³¹,Trappe Todd A.⁹^ORCID,Volpi Elena⁶^ORCID,Walsh Martin J.²⁸,Wheeler Matthew T.¹³^ORCID,Willis Leslie¹⁰

Affiliation:

1. University of Kansas Medical Center, Kansas City, Kansas, United States

2. University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

3. East Carolina University, Greenville, North Carolina, United States

4. Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States

5. University of California, Irvine, Irvine, California, United States

6. University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

7. Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

8. Wake Forest University School of Medicine, Biostatistics and Data Science, Winston-Salem, North Carolina, United States

9. Ball State University, Muncie, Indiana, United States

10. Duke University, Durham, North Carolina, United States

11. Pacific Northwest National Laboratory, Oregon Health and Science University, Portland, Oregon, United States

12. National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States

13. Stanford University, Stanford, California, United States

14. The University of Alabama at Birmingham, Birmingham, Alabama, United States

15. University of Michigan, Ann Arbor, Michigan, United States

16. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States

17. Advent Health - Translational Research Institute, Orlando, Florida, United States

18. The University of Alabama at Birmingham, School of Public Health, Birmingham, Alabama, United States

19. Georgia Institute of Technology, Atlanta, Georgia, United States

20. University of Pittsburgh, Pittsburgh, Pennsylvania, United States

21. Department of Genetics, Stanford University, Stanford, California, United States

22. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States

23. Duke University Medical Center, Durham, North Carolina, United States

24. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States

25. University of Florida, Gainesville, Florida, United States

26. Department of Pathology, Stanford University, Stanford, California, United States

27. Cedars Sinai Medical Center, Los Angeles, California, United States

28. Icahn School of Medicine at Mount Sinai, New York, New York, United States

29. ETH-Zurich, Zurich, Switzerland

30. Wake Forest University, Winston-Salem, North Carolina, United States

31. Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States

32. University of Texas Medical Branch, Galveston, Texas, United States

Abstract

The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will be the first large trial to isolate the effects of structured exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activity. By generating a compendium of the molecular responses to exercise, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. Presented here is the design, protocols, and procedures for the MoTrPAC human studies.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00102.2024

Reference40 articles.

1. The Physical Activity Guidelines for Americans

2. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

3. Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults

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