Skeletal myopathy in a rat model of postmenopausal heart failure with preserved ejection fraction-Reference-Cited by-同舟云学术

Skeletal myopathy in a rat model of postmenopausal heart failure with preserved ejection fraction

Published:2022-01-01 Issue:1 Volume:132 Page:106-125
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Kelley Rachel C.¹^ORCID,Betancourt Lauren¹,Noriega Andrea M.¹,Brinson Suzanne C.¹,Curbelo-Bermudez Nuria¹,Hahn Dongwoo¹^ORCID,Kumar Ravi A.¹,Balazic Eliza¹,Muscato Derek R.¹,Ryan Terence E.¹^ORCID,van der Pijl Robbert J.²³,Shen Shengyi²,Ottenheijm Coen A. C.²³,Ferreira Leonardo F.¹^ORCID

Affiliation:

1. Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida

2. Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona

3. Department of Physiology, Amsterdam UMC, Amsterdam, The Netherlands

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a condition with phenotype-specific features highly prevalent in postmenopausal women and skeletal myopathy contributing to disease development and progression. We advanced a rat model of postmenopausal HFpEF with key cardiovascular and systemic features of the disease. Our study shows that the skeletal myopathy of postmenopausal HFpEF includes loss of limb muscle-specific force independent of atrophy, mitochondrial dysfunction, and oxidized shift in redox balance.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00170.2021

Reference137 articles.

1. Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

2. Heart Failure With Preserved Ejection Fraction In Perspective