Efficacy and toxicity of the DPCPX nanoconjugate drug study for the treatment of spinal cord injury in rats-Reference-Cited by-同舟云学术

Efficacy and toxicity of the DPCPX nanoconjugate drug study for the treatment of spinal cord injury in rats

Published:2022-08-01 Issue:2 Volume:133 Page:262-272
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Gao Xiaohua¹²,Hassan Md. Musfizur³,Ghosh Samiran⁴,Mao Guangzhao³,Sankari Abdulghani¹²⁵^ORCID

Affiliation:

1. Division of Pulmonary/Critical Care & Sleep Medicine, Department of Internal Medicine, Wayne State University, Detroit, Michigan

2. John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan

3. School of Chemical Engineering, University of New South Wales (UNSW Sydney), Sydney, New South Wales, Australia

4. Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan

5. Department of Medical Education, Ascension Providence Hospital, Southfield, Michigan

Abstract

The intradiaphragmatic administration of nanoconjugate is safe and has the promise to significantly reduce the therapeutic dosage for the treatment and achieve long-term and possibly permanent recovery in respiratory muscle dysfunction after SCI. No toxicity of nanoconjugate was found in any of the experimental animals.

Funder

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00195.2022

Reference39 articles.

1. Effect of Spinal Cord Injury on the Respiratory System

2. Traumatic Spinal Cord Injury in the United States, 1993-2012

3. Long-term survival in spinal cord injury: a fifty year investigation

4. Predictors of hospital mortality and mechanical ventilation in patients with cervical spinal cord injury

5. The Identification of a Novel Phosphodiesterase 4 Inhibitor, 1-Ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of Emetogenicity

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Contrasting Experimental Rodent Aftercare With Human Clinical Treatment for Cervical Spinal Cord Injury: Bridging the Translational “Valley of Death”;Journal of Neurotrauma;2023-12-01