Influences on glycocalyx shedding during the Yukon Arctic Ultra: the longest and the coldest ultramarathon

Author:

Steinach Mathias1ORCID,Biere Katharina2,Coker Robert H.3ORCID,Gaul Anna Leonie1,Hoerl Marion2,Jörres Marc1,Kienast Camilla1,Mascarell-Maricic Lea4,Schalt Adriane1,Gunga Hanns-Christian1ORCID,Choukér Alexander25,Rehm Markus5

Affiliation:

1. Center for Space Medicine and Extreme Environments Berlin, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Physiology, Berlin, Germany

2. Laboratory of Translational Research “Stress and Immunity”, Department of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany

3. Montana Center for Work Physiology and Exercise Metabolism, University of Montana, Missoula, Montana

4. Clinic for Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany

5. Department of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany

Abstract

This is the first study to investigate changes in glycocalyx elements in an endurance footrace and first study to investigate exercise-induced shedding in both sexes. This study comprised of an athlete group who finished the ultra-long distance of up to 690 km during the Yukon Arctic Ultra as well as a control group. Results indicate relevant and different shedding of glycocalyx elements heparan sulfate, hyaluronan, and syndecan CD-138. Sex, age, BMI, and covered distance appear to have an influence on the shedding. Other serum parameters indicative of stress appear to be associated with shedding.

Funder

Bundesministerium für Wirtschaft und Energie

Deutsches Zentrum für Luft- und Raumfahrt

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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